Understanding Acute Kidney Injury: Exposing the Hidden RiskKidney diseases typically target Nephrons. These diseases could make it difficult for kidneys to eliminate waste. Genetic issues, trauma, or medications are examples of potential causes. If you have high sugar i.e. diabetes, high blood pressure, or a close relative who has renal disease, your chance of developing kidney disease is increased. Nephron destruction from Chronic kidney disease occurs gradually over the years.