| OX Cosmetic is supplied in single-dose 50 Units and 100 Units of [URL=https://cinerpharma.com/product/buy-tor-bac-bacteriostatic-saline/]bacteriostatic 0.9 sodium chloride for botox[/URL]. Prior to intramuscular injection, reconstitute each
vacuum-dried vial of BOTOX Cosmetic with sterile, preservative-free0.9% Sodium Chloride Injection USP (see Table 1). Draw up
the proper amount of diluent in the appropriate size needle and syringe to obtain a reconstituted solution at a concentration of
4 Units/0.1 mL and a total treatment dose of 20 Units in 0.5 mL for glabellar lines, 24 Units in 0.6 mL for lateral canthallines, and
40 Units in 1 mL for forehead lines and glabellar lines. Then slowly inject the diluent into the vial. Discard the vial if a vacuum does
not pull the diluent into the vial. Gently mix BOTOX Cosmetic with the saline by rotating the vial. Record the date and time of
reconstitution on the space on the label. [URL=https://cinerpharma.com/product/buy-bocouture-botox-online]Bocouture 100 units[/URL] should be administered within 24 hours after reconstitution. During this
time period, reconstituted BOTOX Cosmetic should be stored in a refrigerator (2° to 8°C). BOTOX Cosmetic vials are for single-dose
only. Discard any remaining solution.
Table 1: Dilution Instructions for BOTOX Cosmetic Vials (100 Units and 50 Units)
Diluent* Added to
100 Unit Vial
Resulting Dose
Units per 0.1 mL
Diluent* Added to
50 Unit Vial
Resulting Dose
Units per 0.1 mL
2.5 mL 4 Units 1.25 mL 4 Units
*Preservative-free 0.9% Sodium Chloride Injection, USP Only
Reconstituted BOTOX Cosmetic should be clear, colorless, and free of particulate matter. Parenteral drug products should be
inspected visually for particulate matter and discoloration prior to administration and whenever the solution and the container permit.
Do not freeze reconstituted BOTOX Cosmetic.
2.3 Administration
Draw at least 0.5 mL (for glabellar lines), 0.6 mL (for lateral canthallines), or 1 mL (for forehead lines treated in conjunction with
glabellar lines) of the properly reconstituted toxin into the sterile syringe, preferably a tuberculin syringe and expel any air bubbles in
the syringe barrel. Remove the needle used to reconstitute the product and attach a 30-33 gauge needle. Confirm the patency of the
needle.
Glabellar Lines
Glabellar facial lines arise from the activity of the corrugator and orbicularis oculi muscles. These muscles move the brow m edially,
and the procerus and depressor supercilii pull the brow inferiorly. This creates a frown or “furrowed browâ€. The location, size, and use
of the muscles vary markedly among individuals. Lines induced by facial expression occur perpendicular to the direction of ac tion of
contracting facial muscles. An effective dose for facial lines is determined by gross observation of the patient’s ability to activate the
superficial muscles injected.
In order to reduce the complication of ptosis the following steps should be taken:
• Avoid injection near the levator palpebrae superioris, particularly in patients with larger brow depressor complexes.
• Lateral corrugator injections should be placed at least 1 cm above the bony supraorbital ridge.
• Ensure the injected volume/dose is a ccurate and where feasible kept to a minimum.
• Do not inject toxin closer than 1 cm above the central eyebrow.
Inject 4 Units(0.1 mL) of reconstituted BOTOX Cosmetic intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in
the procerus muscle for a total dose of 20 Units (see Figure 1). Typically the initial doses of reconstituted BOTOX Cosmetic induce
chemical denervation of the injected muscles one to two days after injection, increasing in intensity during the first week.
The duration of effect of BOTOXCosmetic for glabellar lines is approximately 3-4 months |
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