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However, randomized clinical trials cast demur on the energy of vitamin E supply to stop CHD . For example, the Heart Outcomes Prevention Evaluation (HOPE) study, which followed almost 10,000 patients at high risk of inspirit spike or hit for 4.5 years , found that participants taking 400 IU/age of illegitimate vitamin E (268 mg) veteran no fewer cardiovascular events or hospitalizations for heart deficiency or chest pain than participants excitement a placebo.