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Sulfonylureas are most often well put up with. The Chronic Kidney Disease Solution ReviewHypoglycaemia, the most frequent side effect, is more oftenly observed with long-histrionism sulfonylureas (such as chlorpropamide and glyburide), peculiarly in CKD patients for of the fall in nephritic gluconeogenesis and cumulation . Nausea, epidermatous reactions (inclose photosensitivity) and abnormal liver function tests typify other mound-incidence side-effects.